
By Nora T. Gedgaudas
Few are aware that Omega-3 fatty acids, known also as alpha-linolenic acid, EPA and DHA—are easily the single most deficient nutrient in the modern Western diet (second, perhaps, only to water or proper hydration). Insufficient intake of this vital and essential dietary component are linked with virtually every modern disease process, weight problem, affective disorder and learning disability. Unfortunately, more myth, lore and misinformation surround this critical topic (and dietary fats, in general) than almost any other topic in the area of nutritional science. The following is designed to separate fact from fancy, and biochemical theory from living, physiological reality.JUST WHAT IS OMEGA-3 AND WHAT MAKES IT SO IMPORTANT?Deep within the cellular structure (chloroplasts) of leafy green plants (such as grass or plankton) lies a substance known as alpha-linolenic acid—the “parent” form of a class of essential fatty acids (EFA’s) known as omega-3’s. The term “essential” means it cannot be manufactured by the body and MUST be supplied by the diet. When a grass-eating animal or fish comes along and consumes this substance in plant foods a series of enzymatic and metabolic conversions take place to transform alpha-linolenic acid into its derivative forms: EPA (eicosapentanoic acid) and DHA (docosahexanoic acid). Herbivores make these conversions quite readily, though are only able to make limited amounts of DHA. Humans make these conversions much less efficiently and numerous factors may complicate this process. In order to initiate this important metabolic conversion a critical enzyme must be present, known as delta-6-desaturase (D-6-D). It is essential to the process of elongation and desaturation into the active derivative forms of omega-3 (EPA and DHA) from alpha-linolenic acid (found in green, leafy vegetable sources, walnuts and some seeds). Once the body has either consumed or manufactured EPA it can from this manufacture a series of eicosenoids such as Series-3 prostaglandins, thromboxanes and leukotrines. --All are essential to the functioning of the human body as complex hormones functioning on the tissue/cellular-level. DHA, another derivative, makes up a significant portion of the fatty acids in the brain, facilitating visual and cognitive function, forming neuro-receptors for neurotransmitters such as serotonin and dopamine and serving as a storage molecule which the body may re-convert to EPA if needed later on. Omega-3’s also make up a significant portion of all cellular membranes giving them fluidity and helping facilitate all metabolic and bioelectric processes. No one can function optimally without them.Although indispensable for the healthy functioning of the human brain and body, insufficient intake is a nearly unavoidable problem endemic to modern diets and can result in a complex array of symptoms readily contributing to our current national health care crisis.Omega-3 (EPA/DHA) deficiency may be a contributing or causative factor in the following disorders:ADD/HDDyslexiaDepressionWeight gainHeart diseaseAllergiesArthritisViolenceMemory problemsCancerEczemaInflammatory diseasesDiabetesDry skinDandruffPostpartum depressionAlcoholismCrohn’s diseaseIrritable bowel syndromeCirrhosis of the liverPMSHypoglycemia Carbohydrate/sweet cravingsNon-cancerous breast diseaseUlcerative colitisSclerodermaSjogren’s syndromeHypertensionBipolar disorderIrritabilitySoft or brittle nailsLowered immunity/frequent infectionsFrequent urinationFatigueDry, unmanageable hairHyperactivityExcessive thirstDry eyesPoor wound healingLearning problemsAlligator skinPatches of pale skin on cheeksCracked skin on heels or fingertipsThe following illustration shows, in detail, the metabolic pathways and conversions involved in the body’s utilization of Omega 6 and Omega 3: (click on the illustration to enlarge)
